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Three US scientists have won the Nobel Prize in Physiology or Medicine “for their discoveries of molecular mechanisms controlling the circadian rhythm,” otherwise known as our biological clock. Jeffrey C. Hall, Michael Rosbash and Michael W. Young were awarded the prize for their research on how plants, humans and animals adapt their biological rhythm to synchronize with our planet’s day and night cycle, as the earth rotates, in order to control their daily life. Justification: All living organisms on Earth have an internal clock, known as the circadian rhythm, which in humans underlies why we are awake during the day and sleep at night. But our biological clock also helps regulate eating habits, hormone release, blood pressure and body temperature. A person’s well-being is affected when there is a “temporary mismatch between our external environment and this internal biological clock.” For example, disruption to our clocks when someone travels across a number of time zones results in jet lag. An imbalance between lifestyle and rhythm could lead to increased risk for a number of diseases including metabolic diseases, such as diabetes and cancer, and neurodegenerative diseases, such as Alzheimer’s disease. Learning: Research on the body clock has helped scientists improve health. Many drugs now on the market work best when taken at the right time. The cholesterol-cutting drug Mevacor, for example, is taken at night because levels of the enzyme it targets are highest then. The same is true for low-dose aspirin used to reduce blood pressure.
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