Explanation:

- Business: This word refers to the practice of making one’s living by engaging in commerce. It's correctly spelled and commonly used.

- Originate: This means to have a specified beginning or creation. The spelling here is accurate.

- Pursuit: This word is used to describe the action of following or pursuing someone or something. It is spelled correctly.

- Suprimacy: This seems to be a misspelled word. The correct spelling should be "supremacy," which denotes a state of being superior or having the most power.

Option 4 - Suprimacy is the misspelt word.