Explanation:

- Frances Arnold (Option 2) was awarded one-half of the 2018 Nobel Prize in Chemistry for her work on the directed evolution of enzymes, which is a technique for developing proteins with improved or novel functions.

- George Smith (Option 1) and Greg Winter (Option 3) were jointly awarded the other half of the 2018 Nobel Prize in Chemistry for their work on phage display of peptides and antibodies, a process that allows the evolution of new proteins with specific, valuable properties.

- All of these (Option 4) is the correct answer because all three scientists contributed to the field of chemistry and were recognized by the Nobel Committee for their groundbreaking work.