Explanation:

- Offend: To cause someone to feel upset, annoyed, or resentful, often due to a disrespectful or insensitive action or remark.

- Option 1 - Annoy: To irritate or disturb someone, often repeatedly or to the point of causing discomfort.

- Most closely related to "offend" as both can involve causing irritation or discomfort.

- Option 2 - Assuage: To make an unpleasant feeling less intense; to soothe or calm.

- Opposite of offend, which aggravates or upsets.

- Option 3 - Aid: To provide support or assistance; to help.

- Not related to offending or causing upset.

- Option 4 - Assist: To help or give support to make something easier.

- Also unrelated to offending.