Explanation:

- Let's solve the equation step by step:

- Start inside the parentheses: $12+10=22$.

- Replace in the equation: $23-22=1$.

- Enclose by braces: $16\times 1=16$.

- Perform the subtraction of the brackets: $64-16=48$.

- The value of $p$ is 48, which isn't listed correctly in your options.

- The given options are:

- Option 1: 47

- Option 2: 49

- Option 3: 81

- Option 4: 3

- The correct answer isn't listed accurately in the options provided.