Explanation:

- Option 1: Chromosome and genes

- Chromosomes are structures within the nucleus containing DNA.

- Genes are segments of DNA on chromosomes.

- Option 2: Cytoplasm and chromosome

- Cytoplasm is outside the nucleus in the cell.

- Chromosomes are inside the nucleus.

- Option 3: Nucleolus and cytoplasm

- Nucleolus is inside the nucleus.

- Cytoplasm is outside the nucleus.

- Option 4: Protoplasm and chromosome

- Protoplasm includes the cytoplasm and nucleus.

- Chromosomes are in the nucleus part of the protoplasm.

The correct answer is Option 1: Chromosome and genes.