Explanation:

- Vacuoles: Vacuoles are storage structures within cells that hold various compounds. They play roles in storage, waste disposal, and maintaining turgor pressure in plant cells but are not primarily involved in packaging and transporting materials.

- Endoplasmic Reticulum (ER): The ER is involved in protein and lipid synthesis. While the rough ER is studded with ribosomes for protein synthesis, and the smooth ER synthesizes lipids, neither primarily packages materials for transportation.

- Lysosomes: Lysosomes contain digestive enzymes and are involved in breaking down waste materials and cellular debris, but do not package or transport materials.

- Golgi Apparatus: The Golgi apparatus is the cell structure that's principally responsible for packaging materials. It modifies proteins and lipids, then packages them into vesicles for delivery intra-cellularly or for secretion outside the cell.