Which of the following statements about Dr. Har Gobind Khorana is/are correct?
1. He was the first Indian-born Nobel Prize winner in Medicine
2. The award was given for discovering that the order of nucleotides in DNA determines which amino acids are built.
3. He is credited with making the first synthetic genes by cutting and pasting different bits of DNA together.
Select the code from following:
Explanation:
Har Gobind Khorana was an Indian American biochemist who shared the 1968 Nobel Prize for Physiology or Medicine with Marshall W. Nirenberg and Robert W. Holley for research that showed the order of nucleotides in nucleic acids, which carry the genetic code of the cell and control the cell’s synthesis of proteins.
Work on Electron Diffraction
In the 1950s, it was established that genetic information is transferred from DNA to RNA, to protein. One sequence of three nucleotides in DNA corresponds to a certain amino acid within a protein. How could this genetic code be cracked? After Marshall Nirenberg discovered the first piece of the puzzle, the remainder of the code was gradually revealed in the years that followed. Har Gobind Khorana made important contributions to this field by building different RNA chains with the help of enzymes. Using these enzymes, he was able to produce proteins. The amino acid sequences of these proteins then solved the rest of the puzzle.
Note: Ronald Ross was the first Indian-born Nobel Prize winner in Medicine who won the prize in 1902 for his work on transmission of malaria.
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