Explanation:

- Option 1: The Saint Domingue Expedition was indeed a disaster for Napoleon, but it was not a European campaign; it took place in the Caribbean.

- Option 2: The Russian Campaign refers to Napoleon's 1812 invasion of Russia, which was disastrous due to the harsh winter, logistical challenges, and strategic errors.

- Option 3: The Peninsular War was problematic for Napoleon but was not the singular disaster that the Russian Campaign was.

- Option 4: The Continental System was an economic blockade, not a military campaign, though it had its challenges and failures.