Which of the following should be the THIRD sentence after rearrangement ........

Directions ():  Rearrange the following six sentences (A), (B), (C), (D), (E) and (F) in the proper sequence to form a meaningful paragraph; then answer the questions given below them. 
(A) Speculations on future events in the epidemiology, evolution, and biological expression of dengue are presented. 
(B) At the root of the emergence of dengue as a major health problem are changes in human demography and behaviour, leading to unchecked populations of and increased exposure to the principal domestic mosquito vector. Aedesaegypti. Virus-specified factors also influence the epidemiology of dengue. 
(C) The risk of sequential infections, and consequently the incidence of DHF, has risen dramatically, first in Asia and now in the Americas. 
(D) A severe form, dengue haemorrhagic fever (DHF), is an immunopathologic disease occurring in persons who experience sequential dengue infections. 
(E) In the last 20 years the incidence of dengue fever epidemics has increased and hyper endemic transmission has been established over a geographically expanding area. 
(F) Dengue viruses are members of the Flaviviridae, transmitted principally in a cycle involving humans and mosquito vector.

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