Consider the following statements regarding the Chronic myelogenous leukemia (CML)
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It is blood cancer that starts in the blood-forming myeloid cells or stem cells in your bone marrow.
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This type of cancer affects the white blood cells.
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Patients with CML have an abnormal chromosome in their blood cells called the Philadelphia chromosome.
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People with CML are typically born with the Philadelphia chromosome.
Select the correct statement.
1,2&4 only
Incorrect Answer2,3&4 only
Incorrect Answer1,2&3 only
Correct AnswerAll of the above
Incorrect AnswerExplanation:
Only statements 1,2&3 are correct.
Statement 4 is incorrect: No one is born with the Philadelphia chromosome; rather it is a result of a genetic accident that happens in a blood-forming stem cell in the bone marrow.
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Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate.
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It's a type of cancer that starts in certain blood-forming cells of the bone marrow. Bone marrow is the spongy tissue inside bones where blood cells are made.
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The mutation causes the stem cells to produce too many underdeveloped white blood cells. It also leads to a reduction in the number of other blood cells, such as red blood cells.Consequently, the peripheral blood cell profile shows an increased number of granulocytes and their immature precursors, including occasional blast cells.
Hence option 3rd is correct.
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By: Shubham Tiwari