Explanation:

- Indignation: A feeling of anger or annoyance provoked by what is perceived as unfair treatment.

- Option 1: Offense: Generally refers to insult or a breach of a law or rule; it can also mean being upset over something perceived as wrong, which is closely related to indignation.

- Option 2: Designation: Refers to the act of naming or appointing someone to a position. Not related to indignation.

- Option 3: Resignation: The acceptance of something undesirable but inevitable, or the act of leaving a job or position. Not related to indignation.

- Option 4: Defence: The action of defending from or resisting attack. Not related to indignation.

- Correct Answer: Option 1: Offense