Explanation:

- The passage talks about the dual nature of science. It is described as both a blessing and something that has negative effects.

- The phrase "terrible instruments of _____" points toward something harmful or destructive.

- Option 1: destruction – This word fits perfectly as it refers to science's role in creating things like weapons and harmful technology.

- Option 2: happiness – This doesn't apply to "terrible instruments," as happiness is positive.

- Option 3: convenience – Although science provides convenience, it doesn't fit the context of "terrible instruments."

- Option 4: nature – This doesn't logically relate to the context of harm or negativity.