Explanation:

• Reverse Vaccinology is defined as use of genomic information with the aid of computers for the preparation of vaccines without Culturing Microorganism.
• It helps in the examination of the genome of an organism in order to identify novel antigens and epitopes that might constitute Vaccine Candidates.
• It has been used for developing vaccinations for meningococcal and staphylococcal infections all through the world.
• The basic idea behind reverse vaccinology is that an entire pathogenic genome can be screened using bioinformatics approaches to find genes. 
• Those genes are filtered for desirable attributes that would make good vaccine targets such as outer membrane proteins. Once the candidates are identified, they are produced synthetically and are screened in animal models of the infection.