With reference to the SIRT1 consider following statements A study by researchers from Tata Institute...........

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With reference to the SIRT1, consider following statements

A study by researchers from Tata Institute of Fundamental Research, Mumbai (TIFR) has recently revealed the role of glucose in regulating liver functions and ageing.
The group has discovered that glucose controls the functions of a protein SIRT1 which in turn maintains everyday feed-fast cycles and is also associated with longevity.
SIRT1 protein levels are known to increase during fasting and decrease during feed.

Select the correct statement.

1&2 only

2&3 only

1&3 only

All of the above

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Explanation:

A study by researchers from Tata Institute of Fundamental Research, Mumbai (TIFR) has revealed the role of glucose in regulating liver functions and ageing. An enzyme that goes by the name SIRT1 is known to be associated with regulation of metabolic activities and also ageing and hence has become a target of therapeutics. The recent study by researchers from TIFR shows that glucose controls the function of SIRT1 directly. A shortage or absence of this control can lead to a diabetic-like state, while excess feeding and sustained low levels of SIRT1 can lead to obesity and enhanced ageing. This study paves the way to regulating this modification, which might be beneficial in tackling lifestyle disorders and ageing related diseases. ?