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With reference to the Pan-Cancer Analysis of Whole Genomes (PCAWG), consider the following statements:
Which of the statements given above is/are correct?
1&2 only
2&3 only
1&3 only
All of the above
A major international collaboration called the Pan-Cancer Analysis of Whole Genomes (PCAWG), in which researchers has published a series of papers after analysing 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types. They have concluded that “On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete”. This is the largest genome study ever of primary cancer. Various kinds of cancers required to be studied separately because cancers of different parts of the body often behave very differently from one another; so much so that it is often said that cancer is not one disease but many. Previous studies had focused on the 1 per cent of the genome that codes for proteins. The Pan Cancer Project explored, in considerably greater detail, the remaining 99 per cent of the genome, including key regions that control switching genes on and off. One in 10 Indians will develop cancer during their lifetime, and one in 15 Indians will die of cancer, according to a recent World Health Organization (WHO) report. The Northeastern states, Uttar Pradesh, Rajasthan, West Bengal, Haryana, Gujarat, Kerala, Karnataka and Madhya Pradesh account for 44% of the cancer burden in India, says a recent analysis, published in The Lancet Global Health, that looked about 9.7 million deaths that happened in India in 2017. Hence both statements are correct
By: Shubham Tiwari ProfileResourcesReport error
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