Explanation:

- Handicraft Industry: This industry suffered significantly due to de-industrialization, especially in colonial times. Traditional artisans faced competition from machine-made goods, leading to a decline in demand for handmade items.

- Correct Answer: Handicraft (Option 3)

- Cotton Industry: During de-industrialization, this industry faced challenges due to competition with imported cotton goods. However, it was not the most affected compared to handicrafts.

- Coal Industry: This sector was impacted by de-industrialization but not as severely. It continued to be crucial for energy until more recent industrial transitions.

- Iron Ore Industry: It was less affected by earlier phases of de-industrialization, as iron ore continued to be essential for various industrial processes.