Explanation:

- Statement-1: A and B are a married couple.

- Statement-2: D is the father of C.

- Statement-3: E is D's son.

- Statement-4: A and C are sisters.

To determine E's relationship to B:

- From Statements 1 and 4, A is B's wife and C's sister.

- From Statement 2, D (E's father) is also C's father, making A and C siblings. Therefore, A is also E's sibling through marriage.

- From Statement 3, E is D’s son, making E A's sibling by blood since A is D's child as well. Thus, E is B's brother-in-law.

All four statements are needed to conclude this relationship.

All the four statements together are sufficient to answer the Question, which corresponds to Option 3.